Percutaneous balloon valvuloplasty for mitral stenosis is a well-established technique to treat mitral stenosis. In fact, it really is preferred in patients who have appropriate anatomy based on published criteria or who are not surgical candidates (after a thorough risk/benefit assessment and discussion with the medical team and patient). The MitralClip is currently approved for inoperable patients with mitral regurgitation due to prolapse. The MitraClip trial is also being studied in the COAPT trial for functional mitral regurgitation. Details of the trial can be found at: Link to Clinical Trials.Gov (COAPT Trial Details) There are a number of other percutaneous devices in various phases of development for mitral regurgitation in high risk patients.